We surmise that results obtained from the experiments described in this section cannot serve to understand the role of INaL in arrhythmogenesis.
1. Van Driessche W, Lindemann B: Amount reliance from currents owing to unmarried sodium-choosy pores within the frog epidermis. Character. 1979; 282 (5738): 519-520 PubMed Abstract | Author Full Text
It indicates new good findings put forward from this manuscript are perhaps not justified and i also usually do not approve the latest manuscript within form
The fresh new article authors keeps explained a number of the questions I raised in my personal previous review. Regrettably, all big troubles haven’t been managed through this revise. Whenever i manufactured in my prior opinion, I deem they unlikely that every those individuals circumstances are going to be set merely by a number of extra sentences. Rather you may still find particular important concerns for the fresh construction and, most critically, on investigation.
It indicates the brand new strong findings put forward from this manuscript was maybe not rationalized and that i you should never agree the fresh manuscript within function
The people possess made clear several of the inquiries I increased inside my earlier remark. Unfortuitously, every major issues haven’t been treated by this modify. As buying thesis i stated in my previous feedback, We consider they unrealistic that most those people activities are set merely by several added paragraphs. Instead you can still find certain standard inquiries towards experimental structure and you can, extremely critically, to the analysis.
- The best issue is whenever I adopted the fresh new breakdown regarding the ways in the previous type it absolutely was you’ll be able to so you can decode, with almost perfect precision, one arbitrary stimuli names I picked. Select for samples of this reanalysis. It doesn’t matter if we pretend your actual stimulus featured from the a later on date or try consistently switching anywhere between signal and you will quiet, the fresh new decoding is obviously close to best. This really is a sign that decoding has nothing to-do toward real stimulus read from the Transmitter but is opportunistically exploiting additional has on the analysis. The brand new manage research the brand new authors performed, treating this new stimulus names, cannot address this dilemma because it is affected with the same disease. Generally, precisely what the classifier is allegedly using is the time who’s got passed because recording already been.
- The reason for this will be allegedly that the article authors put non-independent study to own education and you will investigations. While I know truthfully (look for area step 3), arbitrary sampling 1 / 2 of data examples from an EEG shade are not separate analysis. Repeating the analysis 5 times – the fresh new manage research brand new article writers did – isn’t a sufficient solution to target it matter. At random trying to find examples regarding an occasion show that features slow alter (such as the sluggish revolution passion you to allegedly dominates this type of tracks significantly less than these situations) often usually incorporate good temporary correlations. Look for TemporalCorrelations.jpg in for 2D density histograms and you can a correlation matrix proving that it.
- Once the modified measures part will bring greater detail now, they still is unclear about what investigation were utilized. Traditional category studies statement just what research enjoys (typical columns regarding analysis matrix) and you can just what findings (typical rows) were utilized. Some thing will be an element however, usually this can be the newest other EEG channels or fMRI voxels etcetera. Observations are usually go out situations. Here I guess the authors switched the fresh new brutal samples for the a some other place playing with dominating component study. That isn’t said if your dimensionality is actually reduced using the eigenvalues. Either way, I suppose the data trials (obtained at 128 Hz) was in fact upcoming used since findings in addition to EEG streams transformed of the PCA were utilized while the provides. The newest stimulus names was basically assigned since On the otherwise Out-of per shot. Some fifty% from examples (and you will names) was then picked randomly getting knowledge, while the other people was utilized getting evaluation. Is this right?